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To determine binding constants by Higuchi and Connors method, the acids solubility was determined by CZE after their agitation in the solutions of HP-γ-CD (with 0.6 molar substitution) at 25 °C for 3 days. The dependences of acids solubility on HP-γ-CD concentration deviated from straight line in the range of high concentration (A N mode ...This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …Phase solubility evaluates the solubility of insoluble guest molecule in the presence of cyclodextrin. It can be obtained by studying the relationship between the guest molecule (1,8-cineole) and the host molecule (HP-β-CD) in the solution, and the stability of IC can be evaluated by stability constant (K s ) ( Higuchi & Connors, 1965 ).Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is …Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.5. Higuchi T, Connors K. Phase-solubility techniques. Advances in Analytical Chemistry and Instrumentation, 4, 1965, 117-212 6. Renu Chadha, Anupam Saini, Poonam Arora, Somnath Chanda. Co-crystals of efavirenz with selected coformers: preparation and characterization. International Journal of Pharmacy and Pharmaceutical Sciences Vol 4, …Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.Phase solubility of GO/β-CD complex. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Excess amounts of GO were added to 10 ml of water solution of β-CD at different concentrations ranging from 0 to 9.5 mM.The objective of the present investigation was to formulation development of solid dispersion of voriconazole using hot-melt, solvent evaporation and combination of these two methods together with Gelucire® 44/14, polaxamer 188 and polyvinyl pyrrolidone (PVP) K30 and the different characteristics like drug content analysis and in vitro release of the solid dispersions were investigated.The linear phase solubility diagram follows the A L-type model according to Higuchi and Connors (1965), suggesting the inclusion complex formed between BBH (guest) and β-CD (host) is in molar ratio of 1:1. It is well-known that the most common type of CDs complexes is the 1:1 drug/cyclodextrin complex where one drug molecule forms a complex ...According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google ScholarPhase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article. Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride.Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ...A phase solubility analysis was performed to quantify the extent of improvement. An 819% increase in the solubility of aniracetam was obtained, reaching 36.44 mg/mL. This marked increase enables aniracetam to exist in an aqueous solvent at levels sufficient for parenteral dosing. ... was calculated according to the Higuchi …24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ...Abstract Solubility is one of the most important physicochemical properties studied during pharmaceutical preformulation. For liquid dosage form development, accurate solubility data are essential to ensure the robustness of the finished product.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.Phase-solubility profiles and classification of drug/CD complexes according to Higuchi and Connors . Figure 2. In general, one drug molecule (D) forms a complex with one CD molecule in pure water, and, if the complex is water-soluble, an A L -type phase-solubility diagram is observed ( Table 1 ).The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.Phase solubility evaluates the solubility of insoluble guest molecule in the presence of cyclodextrin. It can be obtained by studying the relationship between the guest molecule (1,8-cineole) and the host molecule (HP-β-CD) in the solution, and the stability of IC can be evaluated by stability constant (K s ) ( Higuchi & Connors, 1965 ).Phase solubility of FA/HP-β-CD complex. Phase solubility studies were carried out according the method described by Higuchi and Connors’s methods (1965). Excess amounts of FA were added to 10 ml of water solution of HP-β-CDs at different concentrations ranging from 0 to 8.5 mM.T. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. 117-212. ... The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state ...Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on …All the phase solubility diagrams displayed a typical AL type diagram (i.e. linear increases in luteolin solubility with increasing CD concentrations) within the concentration range studied, indicating a 1:1 stoichiometry of the complexes between luteolin and the five different CDs studied (Higuchi & Connors, 1965). This means that each ...11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.For this purpose, the phase solubility of curcumin was assessed using Higuchi and Connors. ... Phase-solubility techniques. Advances in. Analytical Chemistry and Instrumentation, 4 (2), 117–212.The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently …The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3.The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...Phase-solubility measurements. Phase-solubility measurements were carried out according to the method of Higuchi and Connors.14 Excess amount of 5-NI. ( ...Phase Solubility Studies. The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors ().The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different …Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0–4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ...7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...24 Oca 2006 ... reported by Higuchi and Connors.17 Excess drug (25 mg) was added to 15 mL of ... Phase-solubility techniques. In: Reilly CN, ed. Advances in ... The apparent solubility of the substrates (adenine, guanosine, Phase Solubility Studies. Phase solubility st Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP-␤-CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP-␤-CD ing different concentrations of HP-␤-CD, ranging from 14.3 mM ... At 298.2–318.2 K and 101.1 kPa, the solubility The effect of a ternary component copolyvidonum on solubility of itraconazole has been studied. Phase solubility studies has been carried out with a rationale of comparing the solubilization efficiency of nanosponges, copolyvidonum and combination. The dispersions were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction … Phase-solubility profiles and classificat...

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Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi a...

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The influence of both temperature and CYD concentration on complex solubility was studied using th...

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PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间:. 1965/01/01. 被引量:. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate...

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Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 201...

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Higuchi T, Connors K. Phase-solubility techniques. Adv Anal . Chem Instr 1965;4:117-22. ... Microwave Irr...

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